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AIM2CERV (Advaxis IMmunotherapy 2 prevent CERVical recurrence) is a global, randomized, 450-patient phase II study evaluating axalimogene filolisbac, or AXAL—an immunotherapy developed to evoke a targeted antitumor response against HPV-expressing tumor cells.

Adjuvant Therapy

Treatment that is given in addition to the primary (initial) treatment.
Adjuvant treatment is an addition designed to help reach the goal.


Advaxis is a biotechnology company focused on the development of immunotherapies to treat multiple types of cancers. Advaxis sponsoring the AIM2CERV clinical trial.


The aorta is the main artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries). The aorta distributes oxygenated blood to all parts of the body through the systemic circulation.

Axalimogene Filolisbac

Axalimogene filolisbac is an immunotherapy technology that targets HPV-associated cancers. AXAL is being evaluated in three additional ongoing clinical trials in HPV-associated cervical cancer.

Clinical Study/Trial

Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. These studies also may show which medical approaches work best for certain illnesses or groups of people.


Cisplatin is a chemotherapy medication used to treat several cancers.


Any of several substances, such as interferon, interleukin, and growth factors that are secreted by certain cells of the immune system and influence other cells.

Double Blind, Placebo Controlled Clinical Trial

A double-blind, placebo-controlled clinical trial is a medical study involving human participants in which neither side knows who’s getting what treatment and a placebo is given to a control group.

Human Papillomavirus (HPV) Cancers

HPV is a group of more than 150 related viruses. Each HPV virus in this large group is given a number which is called its HPV type. HPV cancers include cancer of the cervix, vulva, vagina, penis, or anus.


Immunotherapy is treatment that uses certain parts of a person’s immune system to fight diseases such as cancer. This can be done by stimulating your own immune system to work harder or smarter to attack cancer cells or by giving you immune system components, such as man-made immune system proteins.

Infusion Therapy

Infusion therapy is medication administered using a sterile catheter that is inserted into a vein and secured.

P13K Inhibitors

A phosphoinositide 3-kinase inhibitor (PI3K inhibitor) is a class of medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes, which are part of the PI3K/AKT/mTOR pathway, an important signaling pathway for many cellular functions such as growth control, metabolism and translation initiation.


A lymphocyte of a type produced or processed by the thymus gland and actively participating in the immune response.